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In P13 and P15, who had evidence of collagen flowers on skin biopsy, DNA analysis of COL5A1 and COL5A2 was performed, which did not show abnormalities

Key findings include upregulated glycolysis and impaired mitochondrial function contributing to ATP deficiency, dysregulated lipid metabolism exacerbating oxidative stress and vascular dysfunction, and amino acid imbalances disrupting immune responses and redox homeostasis

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Remarkably, immune checkpoint inhibitor (ICI) treatment targeting the PD-1/PD-L1 pathway is highly effective for metastatic mismatch repair-deficient and microsatellite instability-high (d-MMR/MSI-H) CRC 6

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When you have a blood vessel that's injured, prostaglandins are released at the site of injury to help with the formation of a clot, so that your body can heal the damaged tissue