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The key risk enhancers are genetic FMO3 variants and microbiome composition

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10.1002/9781119769354.ch6 [DOI] [Google Scholar] Luo H., Mo M., Huang X., Li X., Zhang K

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This pro-inflammatory state is further exacerbated by the reduced expression of PPAR and PPAR in zinc-deficient endothelial cells, as these receptors are crucial inhibitors of NF-B signaling, underlining zinc's vital role in preventing sustained inflammation [19]