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Statistical analysis Data were statistically analyzed using SPSS (version 19.0.1, Chicago, Illinois, USA) for Windows

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This prevents food or liquid from washing away any tirzepatide still being absorbed from the sublingual tissues

When GLP-1 binds to its receptor, it amplifies the insulin signaling pathway, causing increased phosphorylation of insulin receptor substrates and activating the PI3K/Akt pathway, which ultimately results in enhanced glucose uptake, utilization within the liver, and reduced production of glucose (gluconeogenesis)

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