Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection
While this is optional for SBIRs, it is mandatory for STTRS
These studies suggest plausibility but not confirmation
The pathogenesis of MASLD is complex, involving lipotoxicity, OS, insulin resistance (IR), and changes in the gut microbiota (GM) (Figure 1), which schematically illustrates the multifactorial etiology and key risk factors including obesity, insulin resistance, and hyperlipidemia
For GSEA, genes were ranked by the t-statistic of the Lm coefficient in the linear mixed-effects model and then analyzed for the enrichment of canonical pathways and Gene Ontology term gene sets obtained from MSigDB v2.5
4 GLUT9 normally regulates urate reabsorption and excretion in the kidneys, helping to maintain urate balance