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Great as a plateau-buster or maintenance tool

This PK-PD disconnect is compatible with a peptide whose mechanism triggers downstream signalling cascades (VEGFR2 activation, fibroblast migration, angiogenesis) that persist well beyond direct peptide presence

This variability explains why some users tolerate semaglutide with minimal issues while others experience more pronounced symptoms

This is not a formal ceiling because no FDA-approved limit exists, but it represents the upper range of what is supported by preclinical scaling and provider experience

Mild nausea and digestive discomfort Some users report mild nausea, particularly when injecting on an empty stomach first thing in the morning

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