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Value of GLP-1 receptor agonists versus long-acting insulins for type 2 diabetes patients with and without established cardiovascular or chronic kidney diseases: a model-based cost-effectiveness analysis using real-world data

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SURPASS-2 (N=1,879) demonstrated tirzepatide 15 mg reduced A1C by 2.37% compared with 1.86% for semaglutide 1 mg at 40 weeks, showing superiority over the current standard-of-care GLP-1 agonist [13]

Additional UK SmPC warnings include diabetic retinopathy complications (particularly with rapid HbA1c improvement), gallbladder disease, and risk of dehydration leading to acute kidney injury

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But these results depend entirely on accurate dosing, which circles back to proper reconstitution and precise measurement