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Conclusion Positioning semaglutide as a therapeutic option targeting neuroinflammation-mediated neuropathology, this review underscores its potential for repurposing as a disease-modifying therapy across diverse neurodegenerative disorders and highlights the urgent need for targeted trials in MS, ALS, FTD, HD, and LBDconditions that remain without effective immunomodulatory treatments despite clear inflammatory origins

Wegovy Dosing Escalation over 16-20 weeks Weeks 1-4: 0.25 mg/week Weeks 5-8: 0.5 mg/week Weeks 9-12: 1.0 mg/week Weeks 13-16: 1.7 mg/week Week 17+: 2.4 mg/week (maintenance) Single-dose pens use one pen per week Ozempic Dosing Escalation over 8+ weeks Weeks 1-4: 0.25 mg/week Weeks 5-8: 0.5 mg/week Week 9+: 1.0 mg/week (if needed) Optional: 2.0 mg/week (max dose) Multi-dose pen one pen lasts ~1 month Oral Wegovy (New in 2026) In January 2026, Novo Nordisk launched oral Wegovythe first pill form of semaglutide approved for weight loss

Patients who start dietary modifications at the beginning of each dose escalation, rather than waiting for symptoms to become severe, tend to report fewer and shorter episodes

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Yan H, Gu W, Yang J et al (2009) Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys

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