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Even complete knockout of the clag3 genes is not lethal, and transport activity is not completely lost in these parasites ( That the CLAG3 proteins were implicated in NPPs was surprising as they do not resemble known transporters, and moreover, it was expected that proteins comprising the NPP channel would be essential for parasite survival given the vital nature of the substrates it transports

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And ferroptosis inhibitor ferrostatin-1 (Fer-1) partially reversed this effect (Wang F

182 PengX.ChenS.WangY.JinM.MeiF.BaoY.et al (2022)