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Of the 8,801 patients on placebo, 701 had one of those major cardiovascular events (or died)

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Semaglutide was originally developed as a once-weekly diabetes medication, meaning millions of people have used it long-term without requiring dose escalation

Because GLP-1 slows gut motility, theres a risk of worsened constipation in IBS-C

For individuals with obesity, type 2 diabetes, or cardiovascular risk factors, the documented benefits of GLP-1 medications on weight, blood sugar, cardiovascular outcomes, and in some cases kidney and liver health are substantial