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Mutant huntingtin (mHTT) induces metabolic and cellular stress through impaired insulin signaling, defective autophagy, mitochondrial dysfunction, oxidative stress, and synaptic loss (171), processes that overlap with pathways modulated by GLP-1RAs

Now, recently there's been some new research coming out that makes a pretty good case for combining hormone replacement therapy or menopause, , hormone therapy with GLP one therapy

The data from large cardiovascular outcome trials have substantially clarified this risk

The protein bands were quantified by Image Lab software version 6 (Bio-Rad Laboratories, Hercules, CA)

Expert Opin Drug Saf 2016;15(6):809-23 Taipale H et al