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The common pathways observed in mood disorders and MetS are characterized by low-grade inflammation, including the presence of elevated APPs and certain proinflammatory cytokines, an increased atherogenic index of plasma, and Castelli risk indices [152]

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however, the supporters of the chemical imbalance extend the chemical factors of imbalance to serotonin, norepinephrine, dopamine, glutamate, hypothalamicpituitaryadrenal (HPA) axis, GABA, glucocorticoids, inflammatory cytokines and brain-derived neurotrophic factor (BDNF) [21]