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At the time of diagnosis of clinical ASCVD in a patient with T2D on a drug regimen that does not include a GLP-1 RA or an SGLT-2 inhibitor with demonstrated cardiovascular benefit
However, our experimental studies with GEP44 revealed that interactions with Y1-R could mask the effects of GLP-1R agonism in isolated pancreatic islets
Clin J Am Soc Nephrol
E.UmansB
Degradation of glucagon-like peptide-1 by human plasma in vitro yields an n-terminally truncated peptide that is a major endogenous metabolite in vivo
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