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Wistar rats (n = 20) weighing 140 -160g were randomly divided into 4 groups of 5 animals each
That helps with tolerability and regulatory readiness, but it doesnt answer efficacy
1hk), tesaglitazar, but not GLP-1RA/tesaglitazar, induced expression of known PPAR target genes in tissues that lack GLP-1R expression, notably the liver ( Fabp4 and Plin2 ) and skeletal muscle ( Arntl and Sema3c ) (Fig
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Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus
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