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Zafereo ME , Yu J, Angelos P, Brumund K, Chuang HH, Goldenberg D, Lango M, Perrier N, Randolph G, Shindo ML, Singer M, Smith R, Stack BC, Steward D, Terris DJ, Vu T, Yao M, Tufano RP

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In wild-type mice, cagrilintide activates c-Fos-expressing neurons in the dorsal vagal complex (DVC), lateral parabrachial nucleus (LPBN), area postrema, and nucleus tractus solitarius brainstem regions critically involved in satiety signaling and suppression of food intake

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Also, the mean A1c level at intensification with either an oral agent or insulin was 8.7, 9.1 and 9.7% for patients taking one, two or three oral agents [8]