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melatonin activates Nrf2 to inhibit oxidative stress/ferroptosis in hypoxic/reoxygenated tubular cells, preventing AKI (94, 102)
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Current Neuropharmacology, 14(8), 857-865
In cancer cell lines, the mTORC1 signal can also promote de novo lipid synthesis through the sterol responsive element-binding protein (SREBP) transcription factors, which induce the expression of metabolic genes responsible for lipid biosynthesis, including fatty acid synthase (FASN) (Duvel et al., 2010)
Common side effects include nausea, vomiting, diarrhea, abdominal pain, or constipation
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