Bent, S., Bertoglio, K., & Hendren, R
careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects
Efficacy and AE-related end points were assessed for the full analysis set (all randomized participants) and the safety analysis set (all randomized participants exposed to 1 doses of randomized treatment), respectively
If youre not eligible for a GLP-1 for any reason, Rex MD also offers Triple Therapy a doctor-trusted treatment plan that combines three oral medications: metformin, bupropion, and topiramate
PMC 7057205
This approach, which we've refined over years of supplying premier research compounds, is the only way to ensure that the variable being tested is the peptide's effect, not the sloppiness of its preparation