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Its also licenced for prescription to help lower the risk of heart attack and stroke for people living with obesity

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*Correspondence: Peng Feng [email protected] Wei [email protected] This article was submitted to Stroke, a section of the journal Frontiers in Neurology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

All mice were housed in specific pathogen-free conditions (light/dark cycle: 12 h, temperature: 20 1 , humidity: 30 40%) with ad libitum access to food and water

The methionine cycle metabolites are further reduced compounding the effects of trisomy 21