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Species differences matter significantly

A single FOXO4-DRI dose clears accessible senescent cells within the circulation and tissues with high vascular permeability, but deeper tissue reservoirs require time for macrophage-mediated clearance of apoptotic material before a second dose can access previously shielded senescent populations

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In healthy states, the body has a ratio of GSH: GSSG of 30:1 up to 100:1