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Nijhoff et al

Additional biomarkers such as homocysteine and methylmalonic acid (MMA) were also considered to evaluate functional deficiency

Without adequate choline, fat can accumulate in the liver, impairing its function

It is supported by research that activation of caspases can be achieved in two ways, intrinsic (or mitochondrial) and extrinsic (or death receptor), both of which can result in a common pathway or stage of execution (143)

Several studies have demonstrated that iron overload can cause oxidative stress damage and induce apoptosis [116] in chondrocytes

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