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The longer duration may have allowed compensatory mechanisms to develop

First, it drains from your NAD + system, one of the central engines of cellular energy production

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A 5-days-on / 2-off variant (dosing MondayFriday, resting the weekend) also appears in the research framing for those studying receptor-sensitivity preservation

These include inflammation modulation, angiogenesis, collagen organization, cell migration, gut barrier support, and tissue remodeling

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