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et al., 2021), suppressing IL1-induced mesangial cells proliferation and ECM production via inhibiting p38 MAPK (Wang et al., 2007), and improving renal fibrosis in CKD by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 ( Interestingly, deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin (Xu et al., 2022)

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