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Use caution during treatment with semaglutide in patients with renal impairment or end-stage renal disease (renal failure)

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10.1007/s11095-022-03302-1

Poor sleep increases cortisol, which impedes weight loss and worsens mood, potentially undermining both medications intended effects

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Semaglutide and AMPK/SIRT1/PGC-1 signaling may display an important role in autophagy, inflammation, oxidative stress and insulin resistance in skeletal muscle, which are core pathogenetic mechanisms of sarcopenia in obesity