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A 2021 review of trials in older adults found magnesium shortened sleep-onset time in pooled results

Magnoflorine inhibited p65 and IkB, which in turn inhibited the activation of NF-B and the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, exerting anti-inflammatory effects and inhibiting the release of IL-6, IL-8, iNOS and COX-2 to subsequently reduce the inflammatory response

doi: 10.1016/b9780126290554.500106 30 SchernthanerReiterMHTrivellinGStratakisCA

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While these findings necessitate confirmation in a larger population, they reveal significant genetic and environment interactions in disease development

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