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When glutamine is deaminated by glutaminase the resulting glutamate can be further deaminated by glutamate dehydrogenase yielding 2-oxoglutarate (-ketoglutarate) which can then be shunted to malate synthesis in the TCA cycle

Experts recommend that patients take specific B12 supplements with about 1,000 micrograms daily for effective results

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Exposure to pristane for 12 or 24 weeks promoted macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, as well as hypercytokinemia of IFN-, TNF-, IL-4, and IL-6

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