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In SURMOUNT-1, approximately 57% of participants on the 15 mg dose achieved at least 20% weight loss, and over 90% lost at least 5% of their body weightthe threshold considered clinically meaningful

Another 2025 review revealed that injection-site reactions are more likely with tirzepatide than with semaglutide (but keep in mind these reactions are almost always mild and temporary)

The active drug is well studied, but a compounded product is not FDA-reviewed, so quality depends on the pharmacy

Wait 5-10 seconds with the needle still inserted, then withdraw in one smooth motion

After reaching your target weight on a standard dose, gradually titrate down to the lowest dose that maintains your results

semaglutide: Which one is right for you