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If constipation persists despite these measures, healthcare providers may consider temporarily delaying dose increases or reducing the tirzepatide dose

Embracing Disruption The investment implications of a slimmer world Hailed in some quarters as wonder drugs and popularized by celebrity endorsements from the likes of Oprah Winfrey and Elon Musk, glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medicines that has taken both the healthcare and investment worlds by storm over the past year

The main message is that obesity treatment and blood pressure management should increasingly be viewed as interconnected rather than separate therapeutic goals, said Muskiet

Additional blood pressure lowering can be accomplished with diuretics, calcium channel blockers, and -blockers

Odgers-Jewell K, Ball LE, Kelly JT, Isenring EA, Reidlinger DP, Thomas R (2017) Effectiveness of group-based self-management education for individuals with type 2 diabetes: a systematic review with meta-analyses and meta-regression

GLP-1s have been used for diabetes treatment since 2005 and for weight management since 2014