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In the UK, NICE guidance (TA875) recommends Wegovy for adults with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities), with lower thresholds for some ethnic groups

Similar manipulation of sensory inputs in the visual cortex, synaptic input deprivation by permanent lesion of the retina, induces the disappearance of a fraction of GABAergic boutons in few hours (Keck et al., 2011), suggesting that the rapid loss of functional inhibitory synapses may represent a general adaptive mechanism to decreased levels of synaptic activity that is conserved in different functional areas of the cortex

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Most researchers see progressive results through all 12 weeks fat loss doesn't plateau at 8 weeks the way caloric restriction results sometimes do

Injection site reactions (erythema, edema, mild discomfort) occur in 815% of reported cases and typically resolve within 13 days

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