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Its applications continue to expand within functional and regenerative medicine

To prevent ROS production from semiquinones, the cytosolic, NRF2-regulated flavoproteins NAD(P)H: quinone oxidoreductases (NQOs) and aldo-keto reductase (AKR) can compete with P450 reductases and convert quinones to a relatively stable hydroquinones (quinols) [35]

10.1016/j.cytogfr.2024.06.002 10

S2CID 259022851

Despite these promising findings, challenges remain with blood-brain barrier permeability and optimal dosing, ultimately requiring further investigation through clinical trials [183,184]

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