glp-1 ckd Repurposing Diabetes Therapies in CKD: Mechanistic Insights, Clinical Outcomes and Safety of SGLT2i and RAs KDIGO 2026: Glucagon-like peptide-1-based therapies

Lin, S.-N

Both peptides are subjects of active research interest with distinct and well-documented mechanisms of action

Nestin is expressed by various types of cells during their differentiation

Since sermorelin supports growth hormone production and TRT addresses testosterone, the therapies target different hormone systems and can complement each other under proper medical management

Prioritizing protein intake (0.5-0.9g/lb of body weight daily) and spreading consumption throughout the day optimizes muscle protein synthesis

The trial also noted increases in certain liver enzymes in some participants, requiring further investigation