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[8] Kalra S, et al

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Defense Dihexa has been studied for pathways involved in protecting neurons from oxidative stress, inflammation, and age-related cognitive decline

PMID 15010535

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These results suggest that the increased glucose uptake and excretion (glucotonic effect) in the distal intestine and colon following metformin administration indicate that metformin acts at these regions to exert its blood glucose-lowering effects