Targeting intermediary metabolism Farnesoid X receptor (FXR) agonists The nuclear FXR agonists may treat MASLD through various mechanisms, including alleviating insulin resistance and exerting direct anti-inflammatory and antifibrotic effects on MASH in both mouse models and human tissues
THEREFORE, clinical trial designers, investors, and regulators need to aim for more #clinicallyrelevant treatment target #endpoints beyond large magnitude wt loss, and also develop various drug #doses for the diverse intended populations and their different needs over time on their #weightmanagement journey
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The weight comes back when the medication stops In the STEP 1 trial extension, published in Diabetes, Obesity and Metabolism (Wilding et al., 2022), patients who discontinued semaglutide regained about two-thirds of their lost weight within one year
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