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Tear fluid small molecular antioxidants profiling shows lowered glutathione in keratoconus

biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6

10.1093/brain/awaa340 Brain 207 SawantN.MortonH.KshirsagarS.ReddyA

Neurological pathophysiology of SARS-CoV-2 and pandemic potential RNA viruses: a comparative analysis

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Consuming this synthetic form in excess of 200 g per meal is suggested to exceed the dihydrofolate reductase capacity (DHFR) to convert folic acid into THF [28]