Consistency is hard when life gets busy
Copper-binding tripeptides most notably GHK-Cu (glycyl-L-histidyl-L-lysine complexed with Cu(II)) are the most-cited compounds in cosmetic and wound-research literature, characterised by Pickart and colleagues across fibroblast collagen-synthesis assays, broad gene-expression modulation, and the antioxidant chemistry of the Cu(II) coordination centre
Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function
J Immunol (2014) 192(6):292031
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Research has found that genes related to renal interstitial fibrosis are significantly upregulated in patients with kidney stones