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The manner in which damaged mitochondria activate mitophagy is determined by three major factors: PINK1, Parkin and ubiquitin chain

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Although pancreatic beta cells normally exhibit low antioxidant activity, HNG was shown to enhance glucose oxidation, increase ATP levels, and elevate reactive oxygen species (ROS) without damaging mitochondrial membranes

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Lancet Oncol 15(6):640647 Bang YJ et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

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