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These lipid shifts alter microglial signaling, as LPCs normally suppress pro-inflammatory pathways, whereas LPE accumulation triggers Toll-like receptor (TLR) activation, amplifying NF-B-mediated release of TNF-, IL-6, and IL-1

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Dose reduction or temporary treatment pause may be considered in consultation with your provider if constipation severely impacts quality of life or does not resolve after 46 weeks of management

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And if animal meat is not part of your diet, you need vitamin B-12 injections or supplements

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