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A small number of participants, between 2.3 and 4.5 percent, reported dysesthesia, a painful or burninglike sensationa result that McCoy says researchers will need to study further to better understand

Many have advocated that the associations between low mood, suicidal behavior and anti-obesity drugs such as GLP-1RAs are confounded by the pre-existing higher prevalence of neuropsychiatric disorders observed in people living with obesity compared with the general population 236

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however, the intracellular signalling mechanisms underlying these effects remain poorly defined