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In addition, Hp induces inflammation in gastric epithelial cells by up-regulating a variety of pro-inflammatory cytokines, such as NF-B, IL-6, IL-8, and TNF- [35]

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GLUD1mediated production of alpha-ketoglutarate (-KG) and the accumulation of ROS trigger migration and invasion by inducing the expression of Snail (25)

Moreover, there is no direct evidence that TZDs damage the structure and function of the heart