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To induce this transformation, tumor cells secrete signaling molecules (e.g., Wnt7a [60], and osteopontin [61, 62]), and release exosomes containing miRNAs (e.g., miR-9 [63] or miR-125b [64]) and proteins like survivin [65]

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Nanoscale Adv (2021) 3(13):394253

Concentration and formulation uncertainty The optimal concentration of PTD-DBM for human topical application has not been established through dose-finding clinical trials

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Individuals with Gastrointestinal Disorders Conditions like Crohns disease or celiac disease can impair B12 absorption