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It mediates most of the systemic effects of growth hormone through agonism at the IGF-1 receptor (IGF-1R), a transmembrane tyrosine-kinase receptor expressed on most tissues

Proceedings of the National Academy of Sciences of the United States of America, 105(51), 2045220457

Veronika H, Camila A C, Lisa M S, Benedikt O, Konstantin F, Anke L N et al

By targeting the GLP-1 hormone pathway, it effectively suppresses appetite and improves blood sugar control, leading to significant weight loss for many users

This triple mechanism distinguishes it from existing approved agents semaglutide, for example, acts on the GLP-1 receptor only, whilst tirzepatide is a dual GIP/GLP-1 receptor agonist and is being investigated to determine whether broader receptor engagement offers additional metabolic benefit