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Diabetes and Metabolism Journal 45(6): 933947

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Like erythropoietin, most of the growth factors isolated have been glycoproteins, are very active in vivo, and in vitro interact with their target cells via specific cell surface receptors, and ultimately (via intracellular signals) affect gene expression, thereby promoting differentiation

The concept of continuous slow-release delivery of a GLP-1RA has been assessed in a trial of the Intarcia ITCA 650

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