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Furthermore, studies have found that verapamil can enhance the neuroprotective effect of berberine by inhibiting the mechanism of P-glycoprotein efflux and preventing changes in calcium homeostasis (Kumar et al., 2016)

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Samples were run on either a SeQuant ZIC-pHILIC LC column, 5 m, 150 4.6 mm (MilliporeSigma, Burlington, MA) with a SeQuant ZIC-pHILIC guard column, 20 4.6 mm (MilliporeSigma, Burlington, MA) or an Atlantis Premier BEH Z-HILIC VanGuard FIT column, 2.5 m, 2.1 mm 150 mm (Waters, Milford, MA)

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Notably, HOISNDs demonstrate high stability and serve as effective agents for MR and fluorescence imagingguided photodynamic therapy (PDT)