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This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)

Blood sugar levels will begin to stabilize early on

Once-monthly GLP-1 injectables are already in clinical trials, and drugs like retatrutide represent a new generation designed to last longer and work harder

De la Rosa, A

However, separate studies offer a useful look at how each medication performs

ZEPBOUND delays gastric emptying and thereby has the potential to impact the absorption of concomitantly administered oral medications [see Drug Interactions (7.2)]