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According to the model, the carbonyl group of the N-terminal peptide bond of 23 is coordinated to the Zn 2+ ion, whereas the terminal amine is fixed by three glutamate carboxylates (Glu431, Glu487, and Glu295) ( 27 , it was anticipated that the hydroxyl group of the tyrosine side chain of 25 makes a hydrogen-bond with Glu494 of IRAP, an interaction that is lost in the case of 27 according to the free energy perturbation (FEP) analysis ( 27 as compared to the analogous compound 25

[DOI] [PubMed] [Google Scholar] 3.National Institutes of Health, National Heart, Lung, and Blood Institute

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Ipamorelin specifically targets growth hormone release without significantly affecting other hormones like cortisol or prolactin

Rihn, S

Nat Rev Mol Cell Biol 8:813824 Brigelius-Flohe R (1999) Tissue-specific functions of individual glutathione peroxidases