Anti-Inflammatory Protection of the Follicle Chronic low-grade scalp inflammation is one of the most underappreciated drivers of hair loss
References: Charbonnel B, Cariou B (2011): Pharmacological management of type 2 diabetes: the potential of incretin-based therapies
Notably, weight loss appeared to be exposure-dependent, with the cohort receiving the maximum dose of 2 mg/day for the entire study exhibiting the greatest weight loss ( Table 2 )
Post-translational redox control of APR (particularly APR1) marks it out as a significant control point in response to glutathione oxidation (Leustek, 2002)
The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]
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