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For patients with type 2 diabetes, discontinuation requires careful consideration of glycemic control and potential need for alternative glucose-lowering therapies

This is impractical for maintenance dosing but the right choice for research protocols that demand fine-grained dose control

While guidelines may be of value, CRNAs should have an extremely high level of suspicion and proceed conservatively in these cases until more high-quality evidence emerges

Their experiences match what clinical studies show

Update An update of this article has been published in the November 2023 issue of Medicine Today and is available here

As with other medications, prescribers may prescribe these medications for off-label purposes, provided it aligns with the accepted standard of care and falls within their scope of practice