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Once liberated, mtDNA is perceived as a foreign-like molecular signature, activating an evolutionarily conserved network of nucleic acid sensors such as cGASSTING, NLRP3 inflammasome, and TLR9 [33]

Nutritional balance plays a key role in optimal wellness, chronic disease prevention and managing the aging process

The raw 16S rRNA sequencing data generated in this study have been deposited in the Genome Sequence Archive (GSA) at the National Genomics Data Center, China National Center for Bioinformation / Beijing Institute of Genomics, Chinese Academy of Sciences, under accession number GSACRA038413

The pathogenesis of DN includes abnormal glucose metabolism, hyperperfusion and hyperfiltration of the kidney, oxidative stress, and inflammation