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All animals were housed in an environment with a controlled temperature of 22 C 1 C, a relative humidity of 50% 1% and a light/dark cycle of 12/12 h

Activation of OXGR1 by binding 2-oxoglutarate leads to the regulation of a signal transduction pathway involving signal transducer and activator of transcription-3 (STAT-3)

Inject on the same day each week

In this sense celecoxib showed to be a safe and a highly effective therapeutical option in resistant bipolar depression, reducing anxiety and accelerating treatment response [335], in a similar way to aspirin [336]

This evidence is further supported in animal models of depression (Tuon et al., 2021)

and (4) synaptic transmission of multiple neurotransmitters