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Journal Of Pharmacology And Experimental Therapeutics, 301(2), 543-550

11 Interestingly, the antidepressant effects of ALC appeared most robust in older adults, suggesting age-related differences in mitochondrial or neurochemical pathways might mediate its psychotherapeutic actions

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Pyrimidine deficiency can reduce tricarboxylic acid cycle activity and impair mitochondrial respiration 16,17

PMID: 31952280 Dubin RL, et al

[2] The primary side effects documented in clinical trials predominantly involve gastrointestinal symptoms, including nausea, vomiting, diarrhoea, and constipation