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This depletion of GSH may facilitate the production of ROS and reactive nitrogen species (RNS) by astrocytes, causing alterations in neuronal proteins such as -synuclein [25]

Inhale deeply for four seconds and then exhale for the same amount of time

The -helical region contains four anti-parallel helices that are close to some of the helices from the -barrel domain [30, 47]

Notably, exposing -3 PUFAs such as DHA (which is thought to exert anti-inflammatory effects 43 ) elicited cytokine production similar to AA (which is thought to exert inflammatory effects) only in Gpx4 -deficient IECs

key to maximizing its benefits