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Under abnormal metabolic conditions, such as hypoxia, ROS are primarily produced by complexes I and III

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Therefore, Gln deficiency has led to immune dysfunction and HA overproduction in people at high risk of COVID-19

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Moreover, HIF-1 plays a central role in regulating immune evasion, glycolysis, metastasis, and tumor progression, particularly in triple-negative breast cancer (TNBC), highlighting its broad impact on tumor biology [162]

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